In vitroreactivation potency of acetylcholinesterase reactivators — K074 and K075 — to reactivate tabun-inhibited human brain cholinesterases

Comparison of in vitro potency of oximes

Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

✍ Kamil Kuca; Jiri Cabal; Jiri Kassa; Daniel Jun; Martina Hrabinová 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB

The potency of currently used oximes to reactivate sarin-inhibited acetylcholinesterase (AChE) in various parts of pig brain and whole pig brain was evaluated using in vitro methods. Significant differences in reactivation potency among all tested oximes were observed. At concentrations (10 - ----4