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Preparative HPLC separation of bambuterol enantiomers and stereoselective inhibition of human cholinesterases

✍ Scribed by Ivana Gazić; Anita Bosak; Goran Šinko; Vladimir Vinković; Zrinka Kovarik


Publisher
Springer
Year
2006
Tongue
English
Weight
192 KB
Volume
385
Category
Article
ISSN
1618-2650

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✍ T. Thomsen; U. Bickel; J. P. Fischer; H. Kewitz 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 252 KB

The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant