Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study
✍ Scribed by Radha Karki; Pritam Thapa; Han Young Yoo; Tara Man Kadayat; Pil-Hoon Park; Youngwha Na; Eunyoung Lee; Kyung-Hwa Jeon; Won-Jea Cho; Heesung Choi; Youngjoo Kwon; Eung-Seok Lee
- Book ID
- 113583273
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 650 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0223-5234
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A variety of (het)aryl‐substituted benzoquinoline derivatives (III) (24 examples) is designed, synthesized and evaluated for their topoisomerase inhibitory activities and their cytotoxicity against several human cancer cell lines.
## Abstract Twentythree chromenopyridines, substituted at the 2‐ and 4‐position with 5‐or 6‐membered heteroaromatics, are synthesized by treatment of pyridinium iodide salts (III) with chromanones (IV) utilizing a modified Kroehnke synthesis.