Differentiation linked regulation of telomerase activity by Makorin-1
β Scribed by Jose Salvatico; Joo Hee Kim; In Kwon Chung; Mark T. Muller
- Book ID
- 106459219
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 426 KB
- Volume
- 342
- Category
- Article
- ISSN
- 0300-8177
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The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio
Telomerase is an enzyme activity consisting of a reverse transcriptase called TERT and an RNA component that adds repeats of a DNA sequence (TTAGGG) to the ends of chromosomes, thereby preventing their shortening. Associations between telomerase activity and proliferation and differentiation of neur