Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor
โ Scribed by Goueli, Basem S; Janknecht, Ralf
- Book ID
- 110067933
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 267 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements an
The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio