Regulation of the human telomerase reverse transcriptase gene
โ Scribed by Ducrest, Anne-Lyse; Szutorisz, Henrietta; Lingner, Joachim; Nabholz, Markus
- Book ID
- 110066303
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 241 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio