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Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

✍ Scribed by Jiyue Zhu; Yuanjun Zhao; Shuwen Wang

Book ID
107691941
Publisher
SP Higher Education Press
Year
2010
Tongue
English
Weight
275 KB
Volume
1
Category
Article
ISSN
1674-800X

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The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio