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Regulation of Telomerase Activity by the Thermodynamic Stability of a DNA⋅RNA Hybrid

✍ Scribed by Hai-Qing Yu; Dong-Hao Zhang; Xiao-Bo Gu; Daisuke Miyoshi; Naoki Sugimoto

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
702 KB
Volume
120
Category
Article
ISSN
0044-8249

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## Background: Telomeric repeat amplification protocol using internal telomerase assay standard (itas) (conventional trap) has detected telomerase activity in various malignant tumors. with conventional trap, it is difficult to differentiate quantitatively low levels of telomerase activity between