Telomerase activity has been found in a variety of malignant tumors but only rarely in benign tumors or normal tissues. In this study, we investigated telomerase activation in 37 ovarian tumors, including benign, borderline and malignant neoplasms. Telomerase activity was detected using the telomeri
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
✍ Scribed by Blasco, María A.; Rizen, Michael; Greider, Carol W.; Hanahan, Douglas
- Book ID
- 109915203
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 914 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1061-4036
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Telomerase is an enzyme activity consisting of a reverse transcriptase called TERT and an RNA component that adds repeats of a DNA sequence (TTAGGG) to the ends of chromosomes, thereby preventing their shortening. Associations between telomerase activity and proliferation and differentiation of neur
The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio