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Differential recruitment of coactivators to the vitamin D receptor transcriptional complex by 1α,25-dihydroxyvitamin D3 analogs

✍ Scribed by Marie K. Schwinn; Hector F. DeLuca


Book ID
116177960
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
481 KB
Volume
465
Category
Article
ISSN
0003-9861

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## Abstract Binding of 1α,25‐dihydroxy vitamin D~3~ to the C‐terminal ligand‐binding domain (LBD) of its receptor (VDR) induces a conformational change that enables interaction of VDR with transcriptional coactivators such as members of the p160/SRC family or the DRIP (vitamin D receptor‐interactin