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The 3-epi- and 24-oxo-derivatives of 1α,25 dihydroxyvitamin D3 stimulate transcription through the vitamin D receptor

✍ Scribed by Serge Messerlian; Xiangming Gao; René St-Arnaud


Book ID
117669264
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
903 KB
Volume
72
Category
Article
ISSN
0960-0760

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1␣,25-dihydroxyvitamin D 3 (1␣,25(OH) 2 D 3 ), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D receptor can directly regulate gene expression by binding to