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Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3

✍ Scribed by Lee A. Zella; Sungtae Kim; Nirupama K. Shevde; J. Wesley Pike


Book ID
116697923
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
503 KB
Volume
103
Category
Article
ISSN
0960-0760

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## Abstract Treatment with 10^βˆ’8^ m 1,25‐dihydroxyvitamin D~3~ for 24 h causes transcriptional activation of the human insulin receptor gene in U‐937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinosito