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Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3

✍ Scribed by B. Maestro; S. Molero; S. Bajo; N. Dávila; C. Calle

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
84 KB
Volume
20
Category
Article
ISSN
0263-6484

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✦ Synopsis

Abstract

Treatment with 10^−8^ m 1,25‐dihydroxyvitamin D~3~ for 24 h causes transcriptional activation of the human insulin receptor gene in U‐937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinositol 3‐kinase inhibitor, causes a greater inhibition of insulin‐stimulated glucose oxidation in 1,25‐dihydroxyvitamin D~3~‐treated cells than in untreated cells. This suggests a stimulation of phosphatidylinositol 3‐kinase activity by 1,25‐dihydroxyvitamin D~3~, which could mediate, at least in part, the potentiation of the insulin response. Copyright © 2002 John Wiley & Sons, Ltd.

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