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Differential expression and release of LFA-3 and ICAM-1 in human melanoma cell lines

✍ Scribed by Carmen Scheibenbogen; Ulrich Keilholz; Werner Hunstein; Stefan Meuer; Thomas Dengler; Wolfgang Tilgen

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 504 KB
Volume: 54
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910540323

No coin nor oath required. For personal study only.

✦ Synopsis

We examined 10 different melanoma cell lines for cellular expression and release of ICAM-I (CD54) and LFA-3 (CD58) and the influence of cytokines, including IFNcx, IFNy and TNFa. Cellular ICAM-I expression and density varies considerably between the melanoma cell lines. While IFNa has no effect on cellular ICAM-I (clCAM-I) expression, IFNy and t o a lesser extent TNFa can effectively up-regulate clCAM-I. Soluble ICAM-I (SICAM-I) is detected in the supernatants of all lines tested, release of SICAM-I correlates with cellular expression. LFA-3 does not much differ in i t s expression level on melanoma lines, and cytokines have little or no effect on i t s expression. Soluble LFA-3 is released by only 6 out of I0 lines. I t s release can effectively be inhibited by IFNy in all lines and by TNFa in one, while IFNa has no effect. These data show that expression and release of LFA-3 and ICAM-I differ between melanoma cell lines. This may be of importance for the interaction of melanoma cells with immune effector cells in vivo.

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