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Enhanced expression of LFA-3 on human T-cell lines and leukemic cells carrying human T-cell-leukemia virus type 1

✍ Scribed by Toshio Imai; Yoshikazu Tanaka; Kenji Fukudome; Shin Takagi; Koichi Araki; Osamu Yoshie

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 653 KB
Volume: 55
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910550520

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✦ Synopsis

Previously, we studied the surface expression of LFA-I (CDI Ia/CD18) and ICAM-I (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-I pro-viruses expressed high levels of ICAM-I. Enhanced expression of ICAM-I was also seen in fresh leukemic cells from ATL patients. In the present study, we systematically examined the surface expression of I 9 different cell-adhesion molecules (CAMS) (the immunoglobulin superfamily, the homing receptors, the integrins, etc.) in a panel of 20 human T-cell lines (6 HTLV-Inegative lines and 14 HTLV-I -positive lines). The surface expression of LFA-3 (CD58) was constantly enhanced in HTLV-Ipositive T-cell lines except for MT-I, an ATL-derived cell line, which was devoid of a number of CAMS including ICAM-I. LFA-3 proteins and mRNA were found at strongly increased levels in HTLV-I -positive T-cell lines.

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