✦ LIBER ✦

Expression of leukocyte adhesion molecules (ICAM-1/LFA-1) related to clinical behaviour in B cell lymphomas

✍ Scribed by Yoshihiro Nozawa; Yoshiko Yamaguchi; Kunihiko Tominaga; Hiroshi Hojo; Masafumi Abe; Haruki Wakasa

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Volume: 10
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900100309

No coin nor oath required. For personal study only.

✦ Synopsis

We investigated the expression of adhesion molecules of lymphocyte function-associated antigen-lu(LFAlu) and its ligand intercellular adhesion molecule-1 (ICAM-1) on 74 well-characterized B cell lymphomas.

The LFA-1 was expressed on B cell lymphomas (2 1/74; 28 per cent), but to a lesser degree than ICAM-1 which was highly expressed (48/74 cases; 64 per cent).

From the results of bone marrow examination of 39 cases with B cell lymphomas, 13 of 16 cases with a lack of ICAM-I molecule showed a higher incidence of marrow involvement, but nine of 23 cases with the expression of ICAM-1 molecule showed a lower incidence.

These findings suggest that the lack of expression of the ICAM-I molecule by B cell lymphomas correlates with bone marrow involvement by lymphoma cells ($ ~0 . 0 5 ) .

Expression of the LFA-1 molecule appears not to correlate with marrow involvement (p < 0.05).

KEY WORDS Adhesion molecule Bone marrow B cell lymphoma Lymphocyte function-associated antigen-1 (LFA-1) Intercellular adhesion molecule-1 (ICAM-1)

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