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Differences in effects of fibrin(ogen) fragments on the activation of 1-glu-plasminogen and 442-VAL-plasminogen by tissue-type plasminogen activator

✍ Scribed by J.H. Verheijen; W. Nieuwenhuizen; D.W. Traas; G.T.G. Chang; E. Hoegee


Book ID
119035113
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
446 KB
Volume
32
Category
Article
ISSN
0049-3848

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit