Differences in Dihydropyrimidine Dehydrogenase Activities Between Gastric and Colorectal Cancer
โ Scribed by Bunzo Nakata; Kazuya Muguruma; Shigehito Yamagata; Kiyotaka Yukimoto; Kiyoshi Maeda; Yukio Nishiguchi; Masaichi Ohira; Yasuyuki Kato; Kosei Hirakawa
- Book ID
- 111578799
- Publisher
- Springer US
- Year
- 2004
- Tongue
- English
- Weight
- 417 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0163-2116
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๐ SIMILAR VOLUMES
It is essential for actively proliferating cells to increase their rate of DNA synthesis to progress through the cell cycle. This is reflected in the increased uracil usage that is a common feature in solid tumours. Thymidine phosphorylase (TP) anabolises formation of pyrimidine nucleosides availabl
## Abstract Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA __de novo__ synthesis and the salvage pathway in cancer cells, respectively. Intratumoral TS and DPD gene expressions were evaluated to determine the correlation between the expression of th