✦ LIBER ✦

Clinical role of orotate phosphoribosyl transferase and dihydropyrimidine dehydrogenase in colorectal cancer treated with postoperative fluoropyrimidine

✍ Scribed by Yukihiko Tokunaga; Hirokazu Sasaki; Tohru Saito

Book ID: 113920446
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 251 KB
Volume: 141
Category: Article
ISSN: 0039-6060
DOI: 10.1016/j.surg.2006.06.025

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Predicting 5-FU sensitivity using human

Predicting 5-FU sensitivity using human colorectal cancer specimens: comparison of tumor dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activities with in vitro chemosensitivity to 5-FU

✍ K. Isshi; T. Sakuyama; T. Gen; Y. Nakamura; T. Kuroda; T. Katuyama; Y. Maekawa 📂 Article 📅 2002 🏛 Springer 🌐 English ⚖ 327 KB

Clinical implications of thymidylate syn

Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy

✍ Masashi Ishikawa; Takayuki Miyauchi; Yutaka Kashiwagi 📂 Article 📅 2008 🏛 BioMed Central 🌐 English ⚖ 367 KB

Orotate phosphoribosyl transferase mRNA

Orotate phosphoribosyl transferase mRNA expression in oral squamous cell carcinoma and its relationship with the dihydropyrimidine dehydrogenase expression and the clinical effect of 5-fluorouracil

✍ Izumi Yoshitomi; Goro Kawasaki; Souichi Yanamoto; Akio Mizuno 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 465 KB

Role of dihydropyrimidine dehydrogenase

Role of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine against non-small cell lung cancer—in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase

✍ Inoue, Kentarou; Takao, Motoshi; Watanabe, Fumiaki; Tarukawa, Tomohito; Shimamot 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 145 KB

The dihydrouracil/uracil ratio in plasma

The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil

✍ R. Ben Fredj; E. Gross; S. Ben Ahmed; H. Hassine; S. Saguem 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 247 KB

The prognostic significance of thymidyla

The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil

✍ Søren Astrup Jensen; Ben Vainer; Jens Benn Sørensen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 350 KB

## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30