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Gender differences in the dihydropyrimidine dehydrogenase expression of colorectal cancers

โœ Scribed by Kazuki Yamashita; Yoshiko Mikami; Masaharu Ikeda; Masahiko Yamamura; Tadahiko Kubozoe; Atsushi Urakami; Kazuhiro Yoshida; Masatoshi Kimoto; Tsukasa Tsunoda


Book ID
117467522
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
133 KB
Volume
188
Category
Article
ISSN
0304-3835

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It is essential for actively proliferating cells to increase their rate of DNA synthesis to progress through the cell cycle. This is reflected in the increased uracil usage that is a common feature in solid tumours. Thymidine phosphorylase (TP) anabolises formation of pyrimidine nucleosides availabl