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Diazanaphthalenes: A 13C NMR investigation on the site of protonation and pKa values

✍ Scribed by Peter van de Weijer; Hans Thijsse; Douwe van der Meer

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
472 KB
Volume
8
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The pH dependence of the ^13^C chemical shifts (δ) of the diazanaphthalenes has been recorded. From this dependence the p__K__~a~ values have been determined using the Henderson‐Hasselbach equation. The change in ^13^C chemical shifts under the influence of nitrogen protonation (Δδ) has been predicted using the Δδ values of quinoline and isoquinoline. The correlation between observed and expected Δδ values of the symmetric diazanaphthalenes is very good. Assuming these changes in chemical shifts to be of general validity, the site of protonation in the asymmetric diazanaphthalenes has been determined by comparison of the expected Δδ values for α‐ and β‐nitrogen protonation with the observed ones. The site of protonation for 1,6‐ and 1,7‐naphthyridine is the β‐nitrogen atom, whereas for cinnoline both monoprotonated species are present in a significant amount.

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