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1H, 13C and 15N NMR observations on the protonation of 1- and 3-deazapurine

✍ Scribed by J. C. Lindon; J. M. Williams; P. Barraclough

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
423 KB
Volume
24
Category
Article
ISSN
0749-1581

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✦ Synopsis

Using 'H, 13C and =N NMR it has been concluded that 3-deazapurine protonates exclusively at N-1 with a pK of about 5.6. The base exhibits rapid tautomerism with proportions of 70:30, with the N-7-H tautomer in the majority. The salt exists predominantly as the N-7-H tautomer. 1-Deazapurine protonates essentially in a 1:l ratio at N-3 and at the imidazole ring, with a pK of about 3.1. This base also exhibits rapid tautomerism with proportions of 30:70, this time with the N-9-H in the majority. The salt also exists in a tautomeric mixture with approximately equal proportions. One form has N-3 and N-9 bearing hydrogens and the other has N-7 and N-9 bearing hydrogens.

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