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Diastereoselective Synthesis of 2-Amino-4-phosphonobutanoic Acids by Conjugate Addition of Lithiated Schöllkopf's Bislactim Ethers to Vinylphosphonates

✍ Scribed by Ruiz, María; Fernández, M. Carmen; Díaz, Aniana; Quintela, José M.; Ojea, Vicente


Book ID
126981596
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
308 KB
Volume
68
Category
Article
ISSN
0022-3263

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Conjugate addition of lithiated Schöllko
✍ Vicente Ojea; Susana Conde; María Ruiz; Ma Carmen Fernández; JoséMa Quintela 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 310 KB

Face-selective 1,6-addition of lithiated SchOllkopf's bislactime ether 5 to 4-substituted, 1,4-or 3,4-disubstituted 1E,3E-butadienylphosphonates 6a-d allows a direct and stereocontrolled access to semi-rigid AP6 analogues, the 2,3-anti-4E 2-amino-6-phosphono-4-hexenoic acid derivatives 4a-c. The rel