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ChemInform Abstract: Conjugate Additions of E-Alkenylphosphonates to Lithiated Schoellkopf′ s Bislactim Ether: Stereocontrolled Access to anti 2-Amino-3- substituted-4-phosphonobutanoic Acids.

✍ Scribed by V. OJEA; M. C. FERNANDEZ; M. RUIZ; J. M. QUINTELA


Book ID
112040207
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
27
Category
Article
ISSN
0931-7597

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✍ Vicente Ojea; Susana Conde; María Ruiz; Ma Carmen Fernández; JoséMa Quintela 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 310 KB

Face-selective 1,6-addition of lithiated SchOllkopf's bislactime ether 5 to 4-substituted, 1,4-or 3,4-disubstituted 1E,3E-butadienylphosphonates 6a-d allows a direct and stereocontrolled access to semi-rigid AP6 analogues, the 2,3-anti-4E 2-amino-6-phosphono-4-hexenoic acid derivatives 4a-c. The rel