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Conjugate additions of E-alkenylphosphonates to lithiated Schöllkopf's bislactim ether: Stereocontrolled access to anti 2-amino-3-substituted-4-phosphonobutanoic acids

✍ Scribed by Vicente Ojea; Ma Carmen Fernández; María Ruiz; JoséMa Quintela


Book ID
103411854
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
300 KB
Volume
37
Category
Article
ISSN
0040-4039

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Conjugate addition of lithiated Schöllko
✍ Vicente Ojea; Susana Conde; María Ruiz; Ma Carmen Fernández; JoséMa Quintela 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 310 KB

Face-selective 1,6-addition of lithiated SchOllkopf's bislactime ether 5 to 4-substituted, 1,4-or 3,4-disubstituted 1E,3E-butadienylphosphonates 6a-d allows a direct and stereocontrolled access to semi-rigid AP6 analogues, the 2,3-anti-4E 2-amino-6-phosphono-4-hexenoic acid derivatives 4a-c. The rel