Diagnosis and therapy with labeled antibodies
โ Scribed by K Kano; S Ito; K Kitazawa
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 246 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0167-5699
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Forty gastric adenocarcinomas in 30 resected stomachs were examined by an endoscopic immunofluorescent technique using fluorescein isothiocyanate (FITCI-labeled antibodies to carcinoembryonic antigen (CEA). Fluorescence images of the tumors were obtained with a newly developed endoscopic television
Polymeric paramagnetic ion chelate molecules were synthesized and covalently linked to monoclonal antibodies. The labeled antibodies retained their antigen binding capacity in vitro while carrying up to an average of 50 paramagnetic ion chelates, enabling specifically bound antibody concentrations l
## METHODS. Nude mice grafted with LS174T human colorectal carcinoma were Epalinges, Switzerland. treated either with 111 megabecquerels (MBq) of iodine-131 labeled bivalent diethylenetriamine pentaacetic acid (DTPA) hapten 20 hours after pretargeting by anti-CEA 1 anti-DTPA-indium bispecific anti