Labeling and conjugation of monoclonal antibodies for cancer diagnosis and therapy
β Scribed by David V. Woo
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 120 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0360-3016
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Chlorin e6 ( Ce 6) was conjugated with anti-tumor monoclonal antibody ( IgG 2 b ) to increase its binding affinity for tumors. The Ce 6 was activated by N -hydroxysuccinimide and directly conjugated with IgG 2 b ( IgG 2 b β Ce 6) via peptide bonds. An average of 11 Ce 6 molecules were coupled to eac