✦ LIBER ✦

Developmental Toxicity of JP-8 Jet Fuel in the Rat

✍ Scribed by James R. Cooper; David R. Mattie

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 324 KB
Volume: 16
Category: Article
ISSN: 0260-437X
DOI: 10.1002/(sici)1099-1263(199605)16:3<197::aid-jat331>3.0.co;2-j

No coin nor oath required. For personal study only.

✦ Synopsis

JP-8 aviation fuel is being phased in as a replacement for both JP-4 and JP-5 jet fuels presently in use by the Air Force and Navy, respectively. At the present time, 11% of active-duty Air Force personnel are women of child-bearing age. This study was undertaken to determine the threat posed to the unborn fetus should female active-duty personnel come in contact with JP-8 while pregnant. Time-mated Sprague-Dawley rats were dosed orally with JP-8 at 0, 500, 1000, 1500 and 2000 mg kg-' day-' on days 6-15 of pregnancy. The number and type of fetal malformations and variations observed did not differ significantly between dose groups. Dams in the 1000, 1500 and 2000 mg kg-' day-' groups gained significantly less body weight during pregnancy than did control dams. Embryo toxicity was indicated by a significant reduction in fetal body weight in the 1500 and 2000 mg kg-' day-' dose groups.

📜 SIMILAR VOLUMES

Developmental toxicity of OTTO fuel II i

Developmental toxicity of OTTO fuel II in the rat and rabbit

✍ James R. Cooper; Lanfong H. Lee; David A. Macys 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 420 KB

OTTO Fuel I1 (OFII) is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OF11 was a developmental toxin. Phase I of the investigation involved dosing

Inhalation exposure to jp-8 jet fuel alt

Inhalation exposure to jp-8 jet fuel alters pulmonary function and substance p levels in fischer 344 rats

✍ John Pfaff; Kathleen Parton; R. Clark Lantz; Huizhong Chen; Allison M. Hays; Mar 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 776 KB

In a simulated military flightline exposure protocol, Fischer 344 rats (F344) were used to investigate the pulmonary effects of JP-8 jet fuel inhalation. Exposures were nose only and for 1 h daily, Groups were exposed for 7 days (7D) or 28 days (28D). Each exposure group had a matched longitudinal c

Toxicity of chemical mixtures:Proteomic

Toxicity of chemical mixtures:Proteomic analysis of persisting liver and kidney protein alterations induced by repeated exposure of rats to JP-8 jet fuel vapor

✍ Frank A. Witzmann; Robert L. Carpenter; Glenn D. Ritchie; Cody L. Wilson; Alan F 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB 👁 2 views

A test of the community conditioning hyp

A test of the community conditioning hypothesis: Persistence of effects in model ecological structures dosed with the jet fuel jp-8

✍ Wayne G. Landis; April J. Markiewicz; Robin A. Matthews; Geoffrey B. Matthews 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

Detection of oxidative species and low-m

Detection of oxidative species and low-molecular-weight DNA in skin following dermal exposure with JP-8 jet fuel

✍ James V. Rogers; Palur G. Gunasekar; Carol M. Garrett; Mahendra B. Kabbur; James 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB

## Abstract Dermal absorption of JP‐8 jet fuel can lead to skin irritation within hours after exposure. This study detected the formation of oxidative species and low‐molecular‐weight DNA in rat skin as potential indicators of JP‐8‐induced skin injury. At 0, 1, 2, 4 and 6 h after the beginning of a

Developmental toxicity studies of caprol

Developmental toxicity studies of caprolactam in the rat and rabbit

✍ Dr. Shayne C. Gad; Keith Robinson; David G. Serota; Barbara R. Colpean 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 888 KB

Caprolactam was evaluated for developmental toxicity potential in both rats and rabbits by the oral route. In rats dosed on days 6-15 of gestation with 100,500 or 1000 mg/kg/day of caprolactam, the maternal survival rate was significantly lower in the high-dose group and implantation efficiencies we