Inhalation exposure to jp-8 jet fuel alters pulmonary function and substance p levels in fischer 344 rats
✍ Scribed by John Pfaff; Kathleen Parton; R. Clark Lantz; Huizhong Chen; Allison M. Hays; Mark L. Witten
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 776 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
In a simulated military flightline exposure protocol, Fischer 344 rats (F344) were used to investigate the pulmonary effects of JP-8 jet fuel inhalation. Exposures were nose only and for 1 h daily, Groups were exposed for 7 days (7D) or 28 days (28D). Each exposure group had a matched longitudinal control group (LC7 and LC28). Exposure concentrations of 520 mg IT-' caused an increase in dynamic compliance after 7 days of exposure, but compliance changes were not seen with continued exposure (28D, 495 mg m-'). Pulmonary resistance was increased in both 7-and 28-day JP-&exposed groups. Changes in pulmonary function were accompanied by a decrease in substance P concentrations from the bronchoalveolar lavage fluid (BALF). No significant change was observed in BALF levels of 6-keto-PGF,,, the stable metabolite of prostacyclin, which is a marker of endothelial cell function. The JP-8-exposed rats gained significantly less weight during the study period than the LC7 and LC28 groups, and the lungs of the 7D group were heavier by wet lunglbody weight ratio ( Wt,/Wt,). Alveolar clearance of technetium-labelled diethylenetriamine pentaacetate ([99mTc]DTPA) was increased in jet fuel-exposed groups. Light microscopy showed no pathological evidence of lung injury. Recovery from the early pulmonary effects of JP-8 inhalation occurred with continued exposure, as seen by recovery of pulmonary compliance and WtL/wtB.