Developmental toxicity of OTTO fuel II in the rat and rabbit

✍ Scribed by James R. Cooper; Lanfong H. Lee; David A. Macys

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 420 KB
• Volume: 13
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550130405

✦ Synopsis

OTTO Fuel I1 (OFII) is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OF11 was a developmental toxin. Phase I of the investigation involved dosing four groups of time-mated Fischer-344 rats with OFII. The fuel was administered dermally at the rate of 0, 400, 2000 and 4OOO mg kg-' day-'. A significant reduction in body weight was seen at necropsy in dams receiving 2000 and 4OOO mg kg-' day-' of OFII. Fetuses from these dams also weighed significantly less than control fetuses.

Phase I1 of the investigation involved dosing of artificially inseminated rabbits with OFII. The fuel was administered to the skin of the animal's back at the rate of 0, 100, 316 and 1000 mg kg-' day-'. Maternal toxicity was evidenced by a significant reduction in body weight of the dams in the lo00 mg kg-' day-' dose group on days 20 and 25 of gestation. There were no significant differences observed in maternal weight or fetal weight at necropsy. Morphological examination of both rat and rabbit fetuses failed to reveal significant evidence of fetal malformations.