Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit
โ Scribed by Robert L. Clark; Tacey E.K. White; Sally A. Clode; Ian Gaunt; Peter Winstanley; Stephen Andrew Ward
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 194 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1542-9733
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract **BACKGROUND:** Artesunate has been reported to cause embryolethality and malformations when administered orally to rats during organogenesis. The purpose of this study was to determine the most sensitive period(s) for the induction of these effects in order to provide clues about possi
Embryo-fetal development studies with toxicokinetic evaluations were conducted in rats and rabbits after oral or intravenous administration of two endothelin receptor antagonists. In the rat studies, females were administered SB-217242 (0.01-300 mg/kg/day) orally or SB-209670 (0.01-50 mg/kg/day) int