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Artesunate: developmental toxicity and toxicokinetics in monkeys

โœ Scribed by Robert L. Clark; Akihiro Arima; Norbert Makori; Yasuto Nakata; Frederic Bernard; William Gristwood; Andrew Harrell; Tacey E.K. White; Patrick J. Wier

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
336 KB
Volume
83
Category
Article
ISSN
1542-9733

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## Abstract **BACKGROUND:** Artesunate has been reported to cause embryolethality and malformations when administered orally to rats during organogenesis. The purpose of this study was to determine the most sensitive period(s) for the induction of these effects in order to provide clues about possi