In two Segment II Teratology studies, timed-pregnant Crl:CD[BR] (Sprague-Dawley) rats were treated orally (gastric intubation) on days 6-15 of gestation with ibutilide fumarate (ibutilide), a class Ill antiarrhythmic that has been shown to increase the refractory period and action potential duration
Developmental toxicity of bropirimine in rats after oral administration
β Scribed by Marks, Thomas A. ;Poppe, Susan M.
- Book ID
- 112217857
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 613 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-3709
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Pregnant rats were treated with a single intravenous or oral administration of indium chloride (InCl 3 ) on day 9 of pregnancy and their fetuses were examined for growth and malformation on day 20 of pregnancy. By intravenous administration, fetal weight was significantly decreased and the incidence