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Developmental toxicity of ibutilide fumarate in rats after oral administration

โœ Scribed by Marks, Thomas A.; Terry, Roger D.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
715 KB
Volume
54
Category
Article
ISSN
0040-3709

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โœฆ Synopsis

In two Segment II Teratology studies, timed-pregnant Crl:CD[BR] (Sprague-Dawley) rats were treated orally (gastric intubation) on days 6-15 of gestation with ibutilide fumarate (ibutilide), a class Ill antiarrhythmic that has been shown to increase the refractory period and action potential duration of myocardial cells. In the 'Number of fetuses with variationslnumber of litters with this variation; no gross variations were detected. 'Fetuses from only 21 of the 22 litters in the group were subjected to visceral examinations. *Statistically significant dose-response effect, P < 0.05. **Statistically significantly higher than the control group, P < 0.05.

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