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Developmental defects and tumor predisposition in Rb mutant mice

โœ Scribed by Vooijs, Marc; Berns, Anton

Book ID
110062388
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
180 KB
Volume
18
Category
Article
ISSN
0950-9232

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p63 and p73 are functionally and structurally related to the tumor suppressor p53. However, their own role in tumor suppression is unclear. Given the p53-like properties of p63 and p73, we tested whether they are involved in tumor suppression by aging mice heterozygous for mutations in all p53 famil