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Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions

✍ Scribed by Lisiane B Meira; Antonio M.C Reis; David L Cheo; Dorit Nahari; Dennis K Burns; Errol C Friedberg

Book ID
114070363
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
107 KB
Volume
477
Category
Article
ISSN
0027-5107

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## Abstract The EGFR pathway is a critical signaling pathway deregulated in many solid tumors. In addition to the initiation and progression of cancer, the EGFR pathway is also implicated in variable treatment responses and prognoses. Genetic variation in the form of Single Nucleotide Polymorphisms