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Tumor formation in Brca1 conditional mutant mice

✍ Scribed by Chu-Xia Deng

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 314 KB
Volume: 39
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.10069

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## Abstract Summary: The patched gene (__Ptc__) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, __Ptc__ and a number of other pathway members are mutated in some common human cancers. Patched is th