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Patched 1 conditional null allele in mice

✍ Scribed by Tammy Ellis; Ian Smyth; Emily Riley; Scott Graham; Kate Elliot; Monica Narang; Graham F. Kay; Carol Wicking; Brandon Wainwright

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 199 KB
Volume: 36
Category: Article
ISSN: 1526-954X
DOI: 10.1002/gene.10208

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✦ Synopsis

Abstract

Summary: The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc function. genesis 36:158–161, 2003. © 2003 Wiley‐Liss, Inc.

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