Several lines of evidence suggest a relationship between the occurrence of meningiomas and that of breast carcinomas: Both occur more frequently in women than in men, and a higher incidence of meningiomas has been observed in patients with a history of breast carcinoma. Both tumor types also express
Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice
β Scribed by Jennifer Chandler; Peter Hohenstein; Deborah A. Swing; Lino Tessarollo; Shyam K. Sharan
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 350 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1526-954X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract BARD1 (BRCA1βassociated RING domain) was identified by yeast twoβhybrid screening as a protein interacting with BRCA1. Somatic and germline mutations of __BARD1__ have been detected in sporadic breast, ovarian, and endometrial cancers. The present study represents the first description
This study describes how the new massive parallel sequencing technology can be implemented in a diagnostic setting for the breast cancer susceptibility genes (BRCA1 and BRCA2). The throughput was maximized by increasing uniformity in coverage, obtained by a multiplex approach, which outperformed poo
This study was designed to determine the significance of a single intronic base change (IVS5 -12 GβA) found in a family with a history of breast cancer. This change is predicted to form a cryptic splice site resulting in the addition of 11 nucleotides to the BRCA1 transcript. The BRCA1 gene of the r