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Development of Novel Thiazolopyrimidines as CDC25B Phosphatase Inhibitors

✍ Scribed by Stéphanie Kolb; Odile Mondésert; Mary-Lorène Goddard; Denis Jullien; Bruno O. Villoutreix; Bernard Ducommun; Christiane Garbay; Emmanuelle Braud

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
531 KB
Volume
4
Category
Article
ISSN
1860-7179

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## Abstract **The inside cover picture shows** a possible docking pose of a thiazolopyrimidine ligand (stick representation) in the active site of CDC25 shown as a ribbon diagram. The dioxolane moiety is located in the catalytic site loop whereas the dibromohydroxyphenyl part is pointing toward the

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It has been recently reported that some of the CDC25 genes have been implicated in the progression of cell cycle and might display oncogenic properties in mammalian cells. Therefore, the inhibition of this phosphatase may hold promise in the treatment of human cancer. In this study, we demonstrated