Inside Cover: Development of Novel Thiazolopyrimidines as CDC25B Phosphatase Inhibitors (ChemMedChem 4/2009)

✍ Scribed by Stéphanie Kolb; Odile Mondésert; Mary-Lorène Goddard; Denis Jullien; Bruno O. Villoutreix; Bernard Ducommun; Christiane Garbay; Emmanuelle Braud

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 380 KB
• Volume: 4
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.200990016

✦ Synopsis

Abstract

The inside cover picture shows a possible docking pose of a thiazolopyrimidine ligand (stick representation) in the active site of CDC25 shown as a ribbon diagram. The dioxolane moiety is located in the catalytic site loop whereas the dibromohydroxyphenyl part is pointing toward the adjacent “swimming pool”. For more details, see the Full Paper by E. Braud et al. on p. 633 ff.magnified image