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Development of a Scalable Process for 1-β-Methyl Azetidinone: A Carbapenem Key Intermediate †

✍ Scribed by Tewari, Neera; Nizar, Hashim; Rai, Bishwa Prakash; Mane, Avinash; Prasad, Mohan


Book ID
120210885
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
87 KB
Volume
9
Category
Article
ISSN
1083-6160

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The BO-2502A side chain intermediate 3 was prepared via the diastereoselective lactamization of the in situ prepared amino diacid anhydride 14 as a key step. The diastereoselectivity of this step was found to be 53:1 (96% de).