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Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1 H -imidazo[1,2- a ]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors

✍ Scribed by Frutos, Rogelio P.; Eriksson, Magnus; Wang, Xiao-Jun; Byrne, Denis; Varsolona, Richard; Johnson, Michael D.; Nummy, Lawrence; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.


Book ID
126226395
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
79 KB
Volume
9
Category
Article
ISSN
1083-6160

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The synthesis of 5β€²-[14C1] and 3a, 4-[13
✍ M. J. Ackland; M. R. Howard; L. G. Dring πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 318 KB πŸ‘ 1 views

## Abstract 5′‐[^14^C~1~]Panadiplon was prepared in 3 steps starting from [^14^C~1~]cyclopropane carboxylic acid and 3‐(5′‐cyano‐1,2,4‐oxadiazol‐3‐yl)‐5‐(1‐methylethyl)‐imidazo‐[1,5a]‐quinoxalin‐4(5H)‐one. 3a, 4‐[^13^C~2~]Panadiplon was prepared in two steps from ^13^C~2~‐oxalic acid and N‐1‐(1‐met