An efficient synthesis of the side chain intermediate of BO-2502A, a new 1β-methyl carbapenem, via diastereoselective lactamization as a key step

✍ Scribed by Norikazu Ohtake; Yasuyuki Imai; Ryosuke Ushijima

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 555 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)00007-6

✦ Synopsis

The BO-2502A side chain intermediate 3 was prepared via the diastereoselective lactamization of the in situ prepared amino diacid anhydride 14 as a key step. The diastereoselectivity of this step was found to be 53:1 (96% de).