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Development of a Novel Silyl Ether Linker for Solid-Phase Organic Synthesis 1

✍ Scribed by Boehm, Terri L.; Showalter, H. D. Hollis

Book ID
120217464
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
92 KB
Volume
61
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES

Novel silyl linkers for solid-phase synt
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The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of 1Β°a lcohols, 2Β°alcohols and phenols to the solid ph

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A novel silyl linker was designed to facilitate the solid-phase synthesis of protected glycopeptide blocks. Alcohols (carbohydrate, serine, or threonine) were silylated with trialkylchlorosilane containing the p-nitrophenyl group. The nitro group was reduced and succinylated to give the succinanilic

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Treatment of a free amino acid ester with CO 2 followed by exposure to a chlorosilane-containing polystyrene results in its attachment to the solid support. The newly formed silyl carbamate can be employed to build polypeptides at the carboxyl terminus. Cleavage of the (poly)peptide using aqueous HF