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Deuteration of verapamil by acid catalyzed exchange

✍ Scribed by Wendel L. Nelson; Michael J. Bartels

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
202 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

Deuterption of verapamil, 5-[(3,4-dimethoxyphenvlethyl)methylarnino]-2-(3,4-dimet~o~yphenyl)-2-i~opropv~valeronit~-~le, an important calcium channel antagonist was accomplished by direct exchange in 25% 2H SO in 'H,O. terium, which were distributed into both aromatic rings, hut primarily in the ring attached through position 5 of the valeronitrile moiety. Refluxing for 140 hr incorporated 4-6 atoms of deu-2 4

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