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Deuteration of the racemate and the (2S)-(+)-enantiomer of the antiarrhythmic agent disopyramide, 4-diisopropylamino-2-(2-pyridyl)-2-phenylbutyramide

โœ Scribed by Wendel L. Nelson; Janine A. Rees; Sandra J. Hulinek

Book ID
102368075
Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
199 KB
Volume
18
Category
Article
ISSN
0022-2135

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โœฆ Synopsis

Abstract

Deuteration of disopyramide, 4โ€diisopropylaminoโ€2โ€(2โ€pyridyl)โ€2โ€phenylbutyramide, was accomplished in an excess of ^2^H~2~SO~4~ at 125โ€“135ยฐC. Incorporation of 2โ€4 atoms of deuterium occurs with 65% recovery of disopyramide. At higher temperatures (150ยฐC) greater incorporation of deuterium occurs, but substantial decomposition reduces the recovery of disopyramide to 25%.

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