Structures of the racemate and (S)-enantiomer of 7,8-difluoro-3-methyl-2,3-dihydro-4H-[1,4]benzoxazine
✍ Scribed by P. A. Slepukhin; D. A. Gruzdev; E. N. Chulakov; G. L. Levit; V. P. Krasnov; V. N. Charushin
- Book ID
- 106521994
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 472 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1573-9171
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A convenient procedure for preparation of the title compound of->99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.
## Abstract magnified image Substituted 4‐(5‐alkyl‐thiazol‐2‐ylmethyl)‐3,4‐dihydro‐2__H__‐1,4‐benzoxazines and 5‐(2,3‐dihydro‐1,4‐benzoxazin‐4‐ylmethyl)‐4‐methyl‐1‐phenyl‐1__H__‐pyrazol‐3‐ylamines were prepared by the reaction of (2,3‐dihydro‐1,4‐benzoxazin‐4‐yl)‐acetic acid methyl ester and some