✦ LIBER ✦

A facile synthesis of (S)-(−)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted mitsunobu cyclization reaction

✍ Scribed by Soon Bang Kang; Eu Jin Ahn; Youseung Kim; Yong Hae Kim

Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 217 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)82952-8

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✦ Synopsis

A convenient procedure for preparation of the title compound of->99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.

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