## Abstract Deuteration of disopyramide, 4‐diisopropylamino‐2‐(2‐pyridyl)‐2‐phenylbutyramide, was accomplished in an excess of ^2^H~2~SO~4~ at 125–135°C. Incorporation of 2‐4 atoms of deuterium occurs with 65% recovery of disopyramide. At higher temperatures (150°C) greater incorporation of deuteri
Resolution, absolute configuration, and antiarrhythmic properties of the enantiomers of disopyramide, 4-(diisopropylamino)-2-(2-pyridyl)-2-phenylbutyramide
✍ Scribed by Burke, Terrence R.; Nelson, Wendel L.; Mangion, Margaret; Hite, Gilbert J.; Mokler, Corwin M.; Ruenitz, Peter C.
- Book ID
- 127037294
- Publisher
- American Chemical Society
- Year
- 1980
- Tongue
- English
- Weight
- 668 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
## Abstract The synthesls of [d~14~] and [^13^C ^15^N] analogues of the potent antiarrhythmic agent 4‐diisopropylamino‐2‐phenyl‐2‐(2‐pyridyl) butyramide phosphate is described.
Both enantiomers of 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2carboxylic acid 2 and 2,4-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid 3 were prepared via resolution of the corresponding racemic carboxylic acids with (R)-and (S)-1-phenylethylamine, respectively. Absolute config